A Metronidazole-Modeled Central Composite Design Strategy for Plantago ovata Seed Mucilage-Supported Floating Microspheres for Helicobacter pylori Eradication

Background of the research and purpose: Instead using costly synthetic excipients or polymers, authors were in search an economical, easily available, plant-based excipient for making microspheres. Plantago ovata seeds have already been proven to anti-ulcer gastro-protective activity. The same mucilage is used this study as a polymer that can aid floating In study, from was added sodium alginate with Metronidazole treatment eradicate Helicobacter pylori. Methodology: seed (POSM) make To check effects independent variables (POSM SA levels) on entrapment efficiency (EE) time (FT) responses, paper central composite design expert.11 software. microspheres investigated (MNZ) content, size, yield, buoyancy, release during congeniality studies. Results: As POSM content increased microspheres, MNZ increased, greater more POSM. slightly reduced higher levels Conclusion: According investigation, be retained stomach extended periods order H. pylori, assets enhanced by